Analysis Note

ControlHuman gastric mucosa

Application

Research Sub CategoryImmunological Signaling

Anti-ROR2 Antibody, C-terminus detects level of ROR2 & has been published & validated for use in IH(P).

Research CategoryInflammation & Immunology

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Receptor tyrosine kinase-like orphan receptor 2, also known as ROR2, is a member of the Tyr protein kinase family and ROR subfamily of cell surface receptors. Located in the transmembrane, ROR2 is highly expressed during early embryonic development and is associated with chondrocyte formation, cartilage and growth plate maturity. Expression levels of ROR2 subside after 16 days and occur minimally in adults. ROR2 is post translationaly modified by ATM or ATR phosphorylation when DNA damage occurs. Mutations in ROR2 result in brachydactyly type B1 (BDB1), characterized by either hypoplasia or aplasia of the distal phalanges and nails. ROR2 is also associated with recessive Robinow syndrome (RRS), resulting in shortening of limbs, facial dysmorphia and spinal defects.

Immunogen

KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of ROR2

Epitope: C-terminus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Protein G Purified

Format: Purified

Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.

Quality

Evaluated by immunohistochemistry (paraffin) in human gastric mucosa.

Immunohistochemistry(paraffin): 1:50-1:200 dilution of this antibody detected ROR2 in human gastric mucosa.

Specificity

This antibody recognizes the C-terminal region of ROR2.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~105 kDa